Prof. Nick Craddock


Nick Craddock Controversias Psiquiatria Barcelona
Talk The contribution of genetics to psychiatric nosology
Date Friday, April 21st, 2017
Time 11:00 - 11:45


MA, MB,ChB(Hons), MMedSci, PhD, FRCPsych, FMedSci, MD(Hon)

Emeritus Professor of Psychiatry, Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Wales, UK; Visiting Professor, Department of Psychiatry, University of Oxford, UK (craddockn@cardiff.ac.uk).

Nick studied sciences at Cambridge, medicine in Birmingham and psychiatry and genetics in Birmingham, Cardiff and St Louis. Nick specializes in the genetics of mood and psychotic illness. Nick is a Fellow of the Royal College of Psychiatrists and a Fellow of the UK's Academy of Medical Sciences. He was the first Director of Wales' National Centre for Mental Health and Past President of the International Society of Psychiatric Genetics. He was the Honorary Treasurer of the Royal College of Psychiatrists and editorials editor of the British Journal of Psychiatry. Nick has published over 450 scientific papers, was awarded the Stromgren medal for psychiatric research in 2011 and an Honorary doctorate from Birmingham University in 2014.


Familial aggregation has been widely used in the history of psychiatry as a validating criterion for nosological constructs. The findings from family, twin and adoption studies have helped to shape the classifications that we currently use. In the last decade, increased sample sizes together with powerful molecular technologies have provided greatly increased potential for genetic analysis to inform understanding of psychiatric nosology. Recent findings emerging in molecular genetic studies of psychoses show increasing evidence that challenges traditional classification categories – such as the two major categories (schizophrenia and bipolar disorder) that represent the so-called Kraepelinian dichotomy. The emerging evidence suggests the existence of both relatively specific as well as more general relationships between genotype and psychopathology. Evidence from studies of structural genomic variation (copy number variation) suggests the need to reconsider the relationship between schizophrenia and childhood onset neurodevelopmental disorders, such as ADHD and autism. The elucidation of genotype-phenotype relationships is at an early stage, but current findings highlight the need to consider alternative approaches to classification and conceptualization for psychiatric research, and perhaps, practice. This presentation will consider implications of recent research findings for the future of psychiatric diagnostic classification in research and practice.